Back in the olden days I seemed to manage ok with a sidewinder joystick - twist rudder gave me roll control which was important. That was before dual stick controllers were a thing though, but I don't know if I could adapt to that.
Ask yourself. What are you going to do with a throttle in descent?
You need 6DOF to best be able to navigate the environment, you're not flying in straight directions in wide open spaces. You're pitching,Yawing,Rolling and Strafing.
Now, the throttle has more use in wide open spaceflight but even there it you might like 6DOF using full analog control instead of a digital hat switch.