~4 hours in right now and went into 3 MP games.
So far, I like it a lot, but it isn't really setting the world on fire. Very slow paced so far with some small spikes(which is fine to me). FANTASTIC detail in the world, and I am liking the story/characters and general setup a lot. There are a few oddities in the gameplay, mainly with me playing stealthy--they really only have that ONE animation for choking people out? Why do so many games mess that up? There is otherwise some amazing level of animation blending in active combat or the louder takedowns.
Combat itself looks and feels very brutal, but the praise is pretty funny as it is exactly the press A for awesome Dragon Age gif that gets mocked all the time. There is no skill to it, no timing, you just mash a single button for everything.
Shootouts have been fairing better, everything has a good impact and Joel's aiming is done in a way that makes sense, as the AI themselves aren't on perfect autoaim drugs like most other games. They feel sloppy and realer, as it would be. I almost feel Joel actually has too much health though, and I haven't noticed anything like taking a shot to the arm impacting aim that I heard about a lot prerelease.
The sound design and camera work is also stellar. Whatever they do with the camera while you sprint is one of the main reasons the game can feel so tense as you hear runners and clickers, the shaking isn't obnoxious but adds an unease and speed to you moving around that is done very well.
MP is confusing to me, but is a lot different and slower paced compared to uncharted. Seems neat but I need to play more to decide how I feel. Some of the max level booster things seem worrying.