Holy crap. Ok. I knew there was a lot of Renee stuff from looking at Wikipedia. If I get this lot then I don't need 52? 'Cause I was really only interested in that because I read on this thread that it continues the story from Gotham Central.
52 is the next chapter of her story after Gotham Central, it picks up right from the end and follows her as she becomes the question (as well as 5 or 6 other plotlines, but it's a good series honest). Then the Crime Bible 5 Books of Blood is next, that's a 52 Aftermath book and tidies up some of the stuff left over. There was a Montoya-Question backup in Rucka's Batwoman run, and then she pops up again both in Final Crisis and the FC: Revelations mini.
It sounds like a lot of stuff, and it kinda is, but I remember enjoying it all as it was coming out. There was also a miniseries called Huntress: Cry for Blood that has Hunty and the old Question, but I can't remember if renee was init or not, but it's a good book in the Rucka-verse.
Also, have you read No Man's Land? If you're a Renee completest you might enjoy it, it's the first place Rucka starts to use her, and it sets up Two-Face's obsession with her that is picked up later in GC.