I know it's been said a million times, but planning a referendum in 2017 is basically a 'hey, nobody invest in the UK for 4 years' bill. Especially with this EU US Trade deal coming up.
Not to mention its completely useless, no parliament can bind the next parliament.
You'd be surprised as a new business owner how much EU bullshit you have to sift through just to be able to "comply." I'd hazard a guess a lot of businesses, especially ones who are looking worldwide to trade will find the UK more attractive.
One of my manufacturing suppliers has been in business for over 40 years and they said to me its much harder to do business with ANYONE, never mind abroad thanks to the EUs constant moving of goalposts.