These seem to be the major games coming out (I didnt include games that are launching months after the PS3/360 releases on Wii U):
May - Mario Tennis Open (3DS)
August - New Super Mario Bros. 2 (3DS)
Fall - Kirby 20th Anniversary Special Edition (Wii)
Fall - Animal Crossing Stick Out (3DS)
Q3/Q4 - Wii U Launch in North America, Japan and Europe (Wii U)
There are a lot of games with unknown release dates, though we can probably guess on some.
First Party:
??? - Paper Mario (3DS)
??? - Luigi's Mansion 2 (3DS)
??? - Fire Emblem: Awakening (3DS)
??? - Paper Mario (3DS)
??? - Monster Hunter 4 (3DS)
??? - Super Smash Bros. 4 (3DS)
??? - Super Smash Bros 4 (Wii U)
Third Party:
??? - Lego City Stories (Published by Nintendo) (3DS)
??? - Lego City Stories (Published by Nintendo) (Wii U)
??? - Pikmin 3 (Wii U)
??? - New Super Mario Bros. Mii (Wii U)
??? - Assassin's Creed III (Wii U)
??? Killer Freaks (Wii U)
??? Dragon Quest X (Wii U)
??? Tekken (Wii U)
I looked at Nintendos first party studios, and a lot of them are working on mystery projects. I included the known projects, and projects that came out recently.
▪ EAD Comprehensive Group - ???
▪ EAD Group 1 Mario Kart Wii U? The Wii U Sports/Fit shown on the E3 2011 trailer for Wii U?
▪ EAD Group 2 Animal Crossing Stick Out
▪ EAD Group 3 Skyward Sword, Wii U Zelda Tech Demo?
▪ EAD Group 4 New Super Mario Bros. 2, Pikmin 3
▪ EAD Group 5 ???
▪ EAD Tokyo Super Mario 3D Land, ??? (they have two development studios)
▪ Nintendo SPD ??? (Sakamoto is probably crying over the Other M bomba)
▪ Nintendo NSD ???
▪ Nintendo SDD ???
▪ Nintendo Software Technology They recently hired one of the co-creators of Sonic
▪ Monolith Soft ??? (They teased some project)
▪ Retro Studios Hiring noteworthy staff recently
▪ Creatures Inc. Mother 4 (lol)
▪ Brownie Brown ???
▪ Intelligent Systems Paper Mario 3DS
▪ Project Sora Kid Icarus: Uprising, Super Smash Bros. 4
▪ Nd Cube Mario Party 9
▪ HAL Laboratory Kirby: Return to Dreamland, Super Smash Bros. 4 (?)
And this isnt including the plethora of Nintendos partners (Grezzo, Good-Feel, Next Level Games, etc).
Some other notable things:
-Retro Studios hired a lot of staff that made more mature games (like an artist from Uncharted)
-Nintendo Software Technology hired one of the co-creators of Sonic
-Scott Moffit replaced Cammie Dunaway a year ago (I think well see him at E3 this year)
-Nintendo recently purchased a company known for video services on portable devices (Gameboy Advance, iPhone), so we may finally see the movies that Iwata was hinting at E3 2010
-Nintendo Network is going to move toward an XBOX LIVE type service for Wii U (account-based system, etc.)
-eShop is supposed to launch as a website and as an app for other mobile devices as a means of purchasing games for your 3DS system