do you really want to elect a bunch of conservative democrats who'll say "all lives DO matter, but specially blue"?
If it means we get the votes needed to do policing reform or stopping the GOP from fucking this country back into the mid-1890's? Yes.
On a not snarky note, obviously there will be stances that will be unacceptable for any Dem to hold but that doesn't mean we shouldn't be running candidates that are a better fit for their districts. Maybe let them not be as hard line on gun control as Dems in major cities (sort of like Bernie Sanders is) or let them waffle a bit when it comes to issues that are a big deal in their districts.
Having 10 pure left-wing Senators while the GOP holds the rest of the chamber will do nothing for us.