Anyone have any advice for the playing as The Lost?
After having a ridiculous amount of fun unlocking everything else in the game, I'm finding this to be completely miserable and without any redeeming value. It's just fucking awful.
My strategy:
1. Abandon all hope ye who enter here
2. Devil room items are probably most important, they can make or break a run
3. Among these Dead Cat is incredibly powerful. Early Goat Head will give you a ton of devil rooms, thus a lot of (potentially) great upgrades).
4. Reset until you get a) adjacent treasure room with a powerful item b) Basement XL. For a), I reset until I got Holy Mantle*, ???'s Only Friend, Ludovico Technique, Mom's Knife, Max's Head, 0.5 Tech, Mutant Spider, Death's Touch and Lil' Brimstone, though obviously some of these boil down to personal preferences. I also took Cupid's Arrow/Saggitarius since I found piercing shots incredibly helpful. Earlier on I took +all stats items too, but after I got 2/3 objectives I narrowed it down to items listed above (though I might be missing some). Getting a good item at first floor is important since you will get a lot of items that are completely useless later on (+hp, anything with hp regeneration or effect on touch). Unless, b) I ran with Basement XL since Cellar is significantly harder, Basement bosses are all easy and you go straight to devil room.
5. Focus, don't panic. Unless you have Holy Mantle/Dead Cat to fall back on you will lose a ton of promising runs. There is such a ludicrous number of random factors that can screw you up that you can't be prepared for it's not even funny. The game is absolutely not balanced around no-hit runs and you will learn it the hard way.
6. Unlock Stop Watch! If you don't already have it, this can be a lifesaver, though obviously you still need to watch out as it screws up patterns of several enemies.
7. Good Luck!
*Holy Mantle is amazing but is not a run-winner. Unless you get decent damage you are screwed, there are situations where no matter how good you are you are still going to get hit. Even if you have Holy Mantle if you get to Necropolis/Womb with base damage, no tears up or damage up, I swear you won't be able to do it since base damage is abysmal even for Cellar.